.Authors as well as AffiliationsDana-Farber Cancer Institute, Brigham as well as Womenu00e2 $ s Health center as well as Harvard Medical College, Boston, MA, USAToni K. Choueiriu00c2 & u00c2 William G. Kaelin JrHoward Hughes Medical Institute, Chevy Chase, MD, USAWilliam G. Kaelin JrCorresponding authorsCorrespondence to.Toni K. Choueiri or William G. Kaelin Jr.